Kate Bosworth Marries Michael Polish in Intimate Ranch Wedding

"The long-awaited moment has arrived! Kate Bosworth and fiance Michael Polish officially exchanged vows and became husband and wife in an intimate ceremony in Philipsburg, Montana on Saturday, Aug. 31, multiple sources confirm to Us Weekly.

Bosworth, 30, and film director Polish, 42, said "I do" in front of about 50-75 of their closest family and friends at The Ranch at Rock Creek, sources tell Us. The ceremony took place on a mountain top, with the new bride arriving in a stage coach being pulled by two horses. The Win a Date With Tad Hamilton! actress wore a traditional strapless dress with a full train and had her hair up and pulled away from her face.

Guests of the newlweds were given Polaroid cameras, and were asked to post photos on a board in the main lodge that said, "Love is..."

The couple, who met on the set of 2011 film Big Sur, knew from the get-go that their relationship would be a lasting one, Bosworth told the September issue of InStyle UK.

"I never even dated my husband-to-be," she told the magazine. "He said to me after just a few weeks, before we were even together, 'I'm going to marry you.' He just knew."

Polish proposed to Bosworth in August 2012 during a trip to South Korea after the pair first made their public debut as an item at a Coldplay concert just one year earlier.

Before meeting her now-husband, Bosworth dated Alexander Skarsgard and Orlando Bloom.

This article originally appeared on Usmagazine.com: Kate Bosworth Marries Michael Polish in Intimate Ranch Wedding"

Kate Bosworth Marries Michael Polish in Intimate Ranch Wedding

"The long-awaited moment has arrived! Kate Bosworth and fiance Michael Polish officially exchanged vows and became husband and wife in an intimate ceremony in Philipsburg, Montana on Saturday, Aug. 31, multiple sources confirm to Us Weekly.

Bosworth, 30, and film director Polish, 42, said "I do" in front of about 50-75 of their closest family and friends at The Ranch at Rock Creek, sources tell Us. The ceremony took place on a mountain top, with the new bride arriving in a stage coach being pulled by two horses. The Win a Date With Tad Hamilton! actress wore a traditional strapless dress with a full train and had her hair up and pulled away from her face.

Guests of the newlweds were given Polaroid cameras, and were asked to post photos on a board in the main lodge that said, "Love is..."

The couple, who met on the set of 2011 film Big Sur, knew from the get-go that their relationship would be a lasting one, Bosworth told the September issue of InStyle UK.

"I never even dated my husband-to-be," she told the magazine. "He said to me after just a few weeks, before we were even together, 'I'm going to marry you.' He just knew."

Polish proposed to Bosworth in August 2012 during a trip to South Korea after the pair first made their public debut as an item at a Coldplay concert just one year earlier.

Before meeting her now-husband, Bosworth dated Alexander Skarsgard and Orlando Bloom.

This article originally appeared on Usmagazine.com: Kate Bosworth Marries Michael Polish in Intimate Ranch Wedding"

Kylie Jenner Causes 3-Car Pileup 18 Days After Sweet 16

"That didn't take long!

The youngest member of the Kardashian-Jenner clan, Kylie Jenner, hit a bump in the road — literally — just 18 days after ringing in her 16th birthday.

On Wednesday, Jenner was involved in a three-car collision while driving her brand new Mercedes G-Class SUV, worth an estimated $125,000, in L.A.'s posh Calabasas neighborhood.

According to TMZ, Jenner, who's the youngest daughter of Bruce Jenner and Kris Kardashian, rear-ended a Toyota who in turn hit the back of a Subaru SUV.

"There were no injuries, nothing illegal happened, no crime," the Los Angeles County Sheriff's station in Malibu/Lost Hills confirmed to omg!, though they would not say if Jenner, who is still a minor, was involved. "It was purely an accident and the drivers all exchanged information at the scene and one party left before the sheriff's department arrived."

Jenner has yet to confirm the reports, but did take to her Twitter Thursday to post some somber messages. "What do I have to do to not get bothered by something for one day," she said before adding an hour later, "I still shed a tear every once in a while."

While she may be feeling a bit blue, don't expect to see the teen in a less extravagant vehicle following the crash. The E! reality star's family members are big fans of the luxury Mercedes SUV. Kylie and her sister, Kendall, both shared photos of their fleet-like collection on Instagram.

The 16-year-old, whose birthday was August 10, had an "Alice in Wonderland"-themed birthday bash at the AT&T Center in L.A. August 17 with celebrity attendees that included rumored boyfriend Jaden Smith, his sister Willow, "Glee" star Naya Rivera, and rapper Drake.

In a bit of foreshadowing, big sis Kourtney Kardashian tweeted, "Look out world! @kyliejenner is a licensed driver!" two weeks ago."

Christina Aguilera’s Five-Year-Old Shows Off His Smooth Moves

"Christina Aguilera has a new look, a new outlook on life, and a new music video, "Let There Be Love."

The 32-year-old is spreading the message to love more than hate, and she's enlisting the help of one very important man in her life to help get that point across, her five-year-old son, Max.

The singer typically keeps her little man out of the spotlight, but she's giving him a moment to shine in her new video, and it's safe to say he definitely has his mom's moves!

But Max isn't the only one who made a special cameo appearance in the video. Christina's boyfriend, Matthew Rutler, along with pals Nicole Richie and Christina Millian also make guest appearances to support her quest for more acceptance and less judgment in the world.

Though "The Voice" coach has experienced her fair share of criticism over the years, it seems she's really come out on top, not to mention that she looks better than ever in her new video, sporting a sexy black bathing suit.

Check out this vid to see Christina's son's smooth moves, and for more of the latest in entertainment news, tune in to "omg! Insider" on TV tonight!"

Scientists grow "mini human brains" from stem cells

"By Kate Kelland, Health and Science Correspondent

LONDON (Reuters) - Scientists have grown the first mini human brains in a laboratory and say their success could lead to new levels of understanding about the way brains develop and what goes wrong in disorders like schizophrenia and autism.

Researchers based in Austria started with human stem cells and created a culture in the lab that allowed them to grow into so-called "cerebral organoids" - or mini brains - that consisted of several distinct brain regions.

It is the first time that scientists have managed to replicate the development of brain tissue in three dimensions.

Using the organoids, the scientists were then able to produce a biological model of how a rare brain condition called microcephaly develops - suggesting the same technique could in future be used to model disorders like autism or schizophrenia that affect millions of people around the world.

"This study offers the promise of a major new tool for understanding the causes of major developmental disorders of the brain ... as well as testing possible treatments," said Paul Matthews, a professor of clinical neuroscience at Imperial College London, who was not involved in the research but was impressed with its results.

Zameel Cader, a consultant neurologist at Britain's John Radcliffe Hospital in Oxford, described the work as "fascinating and exciting". He said it extended the possibility of stem cell technologies for understanding brain development and disease mechanisms - and for discovering new drugs.

Although it starts as relatively simple tissue, the human brain swiftly develops into the most complex known natural structure, and scientists are largely in the dark about how that happens.

This makes it extremely difficult for researchers to gain an understanding of what might be going wrong in - and therefore how to treat - many common disorders of the brain such as depression, schizophrenia and autism.

GROWING STEM CELLS

To create their brain tissue, Juergen Knoblich and Madeline Lancaster at Austria's Institute of Molecular Biotechnology and fellow researchers at Britain's Edinburgh University Human Genetics Unit began with human stem cells and grew them with a special combination of nutrients designed to capitalize on the cells' innate ability to organize into complex organ structures.

They grew tissue called neuroectoderm - the layer of cells in the embryo from which all components of the brain and nervous system develop.

Fragments of this tissue were then embedded in a scaffold and put into a spinning bioreactor - a system that circulates oxygen and nutrients to allow them to grow into cerebral organoids.

After a month, the fragments had organized themselves into primitive structures that could be recognized as developing brain regions such as retina, choroid plexus and cerebral cortex, the researchers explained in a telephone briefing.

At two months, the organoids reached a maximum size of around 4 millimeters (0.16 inches), they said in a report of their study published in the journal Nature.

Although they were very small and still a long way from resembling anything like the detailed structure of a fully developed human brain, they did contain firing neurons and distinct types of neural tissue.

"This is one of the cases where size doesn't really matter," Knoblich told reporters.

"Our system is not optimized for generation of an entire brain and that was not at all our goal. Our major goal was to analyze the development of human brain (tissue) and generate a model system we can use to transfer knowledge from animal models to a human setting."

In an early sign of how such mini brains may be useful for studying disease in the future, Knoblich's team were able to use their organoids to model the development of microcephaly, a rare neurological condition in which patients develop an abnormally small head, and identify what causes it.

Both the research team and other experts acknowledged, however, that the work was a very long way from growing a fully-functioning human brain in a laboratory.

"The human brain is the most complex thing in the known universe and has a frighteningly elaborate number of connections and interactions, both between its numerous subdivisions and the body in general," said Dean Burnett, lecturer in psychiatry at Cardiff University.

"Saying you can replicate the workings of the brain with some tissue in a dish in the lab is like inventing the first abacus and saying you can use it to run the latest version of Microsoft Windows - there is a connection there, but we're a long way from that sort of application yet."

(Editing by Mark Trevelyan)"

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